There is a known issue in GAMS Studio when it comes to specifying the MIRO location on macOS. Make sure that the path does not stop at /Applications/GAMS MIRO.app, but points to the executable inside the app bundle: /Applications/GAMS MIRO.app/Contents/MacOS/GAMS MIRO. The /Contents/MacOS/GAMS MIRO part is always the same and needs to be appended to the path of the app bundle.